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Synthesis, Characterization and in vitro Screening of Amoxicillin and its Complexes with Ag (I), Cu (II), Co (II), Zn (II) and Ni (II)

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Author(s): Muhammad Imran | Javed Iqbal | Tariq Mehmood | Shoomaila Latif

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 6;
Issue: 5;
Start page: 946;
Date: 2006;
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Keywords: Amoxicillin | metal ions | antibacterial studies | coordination compounds

ABSTRACT
New complexes of Amoxicillin with some transition metal ions such as Ag(I), Cu(II), Co(II), Zn(II) and Ni(II) has been synthesized and characterized on the basis of physical, spectral and analytical data. These complexes have also been screened for their antibacterial activity against several bacterial strains such as Escherichia coli, Staphylococcus aurous, Pseudonomous aerugionosa. The metal complexes showed enhanced antibacterial activity as compared to simple antibiotic. The present study was carried out in the search of target antibiotic moiety instead of broad-spectrum antibiotic.
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