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Synthesis and evaluation of 1,3 Di-substituted schiff, mannich bases and spiro isatin derivatives

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Author(s): Mondal P | Banerjee M | Jana S | Bose A

Journal: Journal of Young Pharmacists
ISSN 0975-1483

Volume: 2;
Issue: 2;
Start page: 169;
Date: 2010;
Original page

Keywords: Analgesic | antipyretic | anti-inflammatory | isatin | Spiro compounds

ABSTRACT
Schiff bases of isatin with aminothiazole, its N-mannich bases and Spiro isatin derivatives were synthesized. Their chemical structures were confirmed by Infrared, 1H-Nuclear Magnetic Resonance data and elemental analysis. Antimicrobial evaluation was performed by the agar diffusion method against four pathogenic bacteria and two pathogenic fungi. Anti-inflammatory activity was tested by carragenin-induced rat paw edema and compounds were evaluated for analgesic action by the acetic acid-induced writhing method; Compounds Aa, Ab and A5, A6 were found to be active against bacteria and fungi. The compounds A3, A6, Aa and Ab showed anti-inflammatory activity, having a percentage protection value of 34.69, 32.65, 38.77 and 36.73 as compared with that of indomethacin, with % protection of 46.93. Similarly, the compounds Aa, Ab and A6 showed analgesic activity, with % protection of 67.51, 64.78 and 49.81 as compared with the standard with % protection of 79.56.
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