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SYNTHESIS AND EVALUATION OF OXAZOLIDINONES HAVING BENZO THIAZINEN MOIETIES AS ANTIMICROBIAL AND ANTI-INFLAMMATORY AGENTS

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Author(s): Jennifer Fernandes | Pankaj Kumar | Abhishek Kumar

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 4;
Issue: 8;
Start page: 260;
Date: 2013;
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Keywords: Oxazolidinones | Benzothiazinen | Antibacterial | Antifungal | Antimicrobial | Anti-inflammatory.

ABSTRACT
Phenyl oxazolidinones were prepared from R-glycidyl butarate and Para bromo aniline, further (3-(4-bromophenyl) methylene oxazolidine-5yl) and substituted benzothiazinen was refluxed resulted in oxazolidinones benzothiazinen moieties. Treatment of these oxazolidinones benzo thiazinen moieties with methane sulfonyl gives its sulphonates on further treatment with sodium azide and tri phenyl phosphine in acetic anhydride gives acetamide derivatives. Further synthesized compounds were characterized by IR, H NMR1 and Mass spectral studies. The synthesized compounds were evaluated for antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and antifungal activity against, Candida albicans and Aspergillus niger. The synthesized compound was screened for their anti-inflammatory activity by carrageenan induced paw-edema method.
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