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Synthesis and evaluation of a series of pyrimidine substituted 1,3,4-oxadiazole derivatives as antimicrobial and anti-inflammatory agents

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Author(s): Sanath Kumar Goud Palusa | Rajgopal H.Udupi | Himabindu V | Ajjanna M Sridhara

Journal: Organic Communications
ISSN 1307-6175

Volume: 4;
Issue: 4;
Start page: 82;
Date: 2011;
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Keywords: 1 | 3 | 4-oxadiazole | pyrimidine | antibacterial | antifungal | anti-inflammatory.

ABSTRACT
Novel pyrimidine substituted 1,3,4-oxadiazole derivatives (11a-k) were synthesized from the condensation of different substituted aromatic carboxylic acids with substituted pyrimidine carboxy hydrazide using POCl3 as condensing agent. Their structures were characterized by physical and spectral studies. The synthesized compounds were evaluated for their in vitro antimicrobial and anti-inflammatory activity. Some of the newly synthesized compounds showed good antimicrobial and anti-inflammatory activities.

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