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Synthesis and evaluation of some new ß-lactam ring containing benzothiazole derivatives as potential antimicrobial agents but less potent antioxidant agents

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Author(s): Meti Neelakantappa, Kuntal Hazra*, L.V.G. Nargund and P. Rashmi

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3409;
Date: 2011;
Original page

Keywords: Benzothiazole | Schiff’s base | ß-lactam | Antimicrobial activity | Antioxidant activity

ABSTRACT
As benzothiazole has proven to be good antimicrobial agent, a novel series of ß-lactam of benzothiazole derivatives were synthesized. A series of 3-chloro-1-(7-chloro-6-fluoro-4-nitrobenzo[d]thiazol-2-yl)-4-substituted phenylazetidin-2-one (6a-f) and their 7th chloro substituted derivative 3-chloro-1-(6-fluoro-4-nitro-7-(substituted phenylamino)benzo[d] thiazol-2-yl)-4-(2-hydroxyphenyl) azetidin-2-one 8(a,b) were synthesized for their antibacterial and antioxidant activity.Structures of the synthesized compounds were elucidated on the basis of elemental analyses and spectral data. The antibacterial activities against two Gram-positivebacteria namely, Staphylococcus aureus (ATCC-25923) and Bacillus subtilis (ATCC 6633) and two Gram-negative bacteria namely, Escherichia coli (ATCC-25922) and Pseudomonas aeruginosa (ATCC-27853) were used for the antibacterial activity. All the compounds tested showed some degree of antimicrobialactivity. Among the series, compounds 8a and 8b exhibited good antibacterial activity profile as compared with the standard procaine penicillin and streptomycin.Whereas they have showed less antioxidant activity as compared to standard ascorbic acid.
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