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SYNTHESIS OF GLABRIN A AND ITS N-METHYLATED ANALOG AS POTENT INSECTICIDAL AGENTS

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Author(s): M. Himaja | G. Vani | Ramana M.V | Karigar Asif | D. Munirajasekhar

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 3;
Issue: 1;
Start page: 91;
Date: 2012;
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Keywords: Glabrin A | cyclohexapeptide | solution phase peptide synthesis | anthelmintic activity and insecticidal activity.

ABSTRACT
Two new cyclohexapeptides, Glabrin A and Glabrin B were isolated from the seeds of Annona glabra. The cyclohexapeptides show simple architectures with highly repeated residue units, which showed moderate antifungal and weak antitumor activities in vitro. The Glabrin A and its N-Methylated analogs were synthesized and were evaluated for their biological activity. The N-methylated peptide antibiotics are found to possess enhanced activity as compared to the unmethylated forms. The structure of the new compounds was confirmed by IR, 1HNMR and Mass spectroscopy. The synthesized compounds were tested for their anthelmintic activity and insecticidal activity.
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