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Synthesis and <i>in vitro</i> antibacterial evaluation of some thiosemicarbazides and thiosemicarbazones

Author(s): Aytak Novinrooz | Farahnaz Motamedi-Sedeh | Morasa Sheikhy | Amir R. Jalilian

Journal: Advances in Molecular Imaging
ISSN 2161-6728

Volume: 05;
Issue: 02;
Start page: 39;
Date: 2012;
Original page

Keywords: Synthesis | Antibacterial | Thiosemicarbazides | Thiosemi-carbazones

In the present study various thiosemicarbazides and thiosemicarbazones were synthesized and screened for their antimicrobial activity. Among the ligands tested, compounds 1, 3, 4 and 5 demonstrated inhibitory effects at 0.4 - 0.5 µM concentrations against E. coli while 1-(4-fluorobenzoyl)-N4-ethyl-thiosemicar-bazide (3) demonstrated the maximum inhibitory effective compound against E. coli, also possessing high water solubility. Instead, compound 3 demonstrated weak antibiotic effects against S. aurous while compounds 4 - 6 demonstrated significant antibacterial effects at 0.4 - 0.42 µM against the latter organism. Chloramphenicol was used as the positive control.
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