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Synthesis and Influence of Two Quinoxalinone Derivatives on Anxiety- and Depressive-Like Responses in Wistar Rat

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Author(s): Redouan Nakache | Brahim Lakhrissi | Fatima Zahra El Mrabet | Aboubaker Elhessni | Ali Ouichou | Bouchra Benazzouz | Abdelhalem Mesfioui

Journal: Neuroscience & Medicine
ISSN 2158-2912

Volume: 03;
Issue: 04;
Start page: 330;
Date: 2012;
Original page

Keywords: Depression | Anxiety | Quinoxalinone Derivatives | Locomotor Activity | Wistar Rats

ABSTRACT
Two new quinoxalinone derivatives have been synthesized adopting the HONG method, and investigated for some neuropharmacological effects (anxiety- and depressive-like responses) in rats. The present experiment sought to determine whether treatment with these compounds produces changes in affective responses. We found that the chronic injection of 6-nitro-2(1H)-quinoxalinone (NQu) showed obvious anxiolytic- and antidepressant-like effects, respectively, measured in the behavioral tests of Elevated Plus Maze (EPM) and Forced Swim Test (FST). At the dose of 30 mg/kg, NQu showed a comparative anxiolytic-like effect in rats as diazepam (Dz) (1 mg/kg), and a comparative antidepressant effect as clomipramine (Clmp) (2 mg/kg; i.p). The 2(1H)-quinoxalinone (Qu) significantly reduced depressive-like responses as evaluated in FST, whereas no anxiolytic-like effect was found as measured by open field test (OF). Additionally, the locomotor activity levels were unaffected by treatment as measured by OF and EPM.

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Tangokurs Rapperswil-Jona

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