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Synthesis and microbial screening of 6-pyridin-4-yl-2, 3-dihydro-1Hpyridazin-4-one derivatives

Author(s): Athar Javed1*, M. S. Bhatia2, Mayuresh Shinde2, Vinod Singh3

Journal: Indian Journal of Pharmaceutical and Biological Research
ISSN 2320-9267

Volume: 1;
Issue: 3;
Start page: 1;
Date: 2013;
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Keywords: 6-pyridin-4-yl-2 | 3-dihydro-1H-pyridazin-4-one | hydrazones | cyclization

6-pyridin-4-yl-2, 3-dihydro-1H-pyridazin-4-one derivatives were synthesized by a simple method. The isonicotinicacid hydrazide was made to react with acetaldehyde and acetone. This results into the formation of the respectivehydrazones. These hydrazones formed were cyclized to the pyridazine derivatives. All synthesized compounds weresubjected to antimicrobial activity.
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