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Synthesis of new derivatives of 1-(3-aminophenyl)-4-benzoyl-5-phenyl-1H-pyrazole-3-carboxylic acid

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Author(s): RAHMI KASIMOGULLAR | BELMA ZENGIN | MAKBULE MADEN | SAMET MERT | CAVIT KAZAZ

Journal: Journal of the Serbian Chemical Society
ISSN 0352-5139

Volume: 75;
Issue: 12;
Start page: 1625;
Date: 2010;
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Keywords: pyrazole-3-carboxylic acid | pyridazin | diazonium salts | cyclocondensation

ABSTRACT
1-(3-Aminophenyl)-4-benzoyl-5-phenyl-1H-pyrazole-3-carboxylic acid (1) was synthesized according to the literature. 2-(3-Aminophenyl)-2,6-dihydro-3,4-diphenyl-7H-pyrazolo[3,4-d]pyridazin-7-one (5) was obtained by the cyclocondensation reaction of 1 with hydrazine hydrate. New pyrazole derivatives of compounds 1 and 5 were synthesized by their reaction with β-diketones, β-ketoesters, β-naphthol, phenol and various other reagents. The structures of the synthesized compounds were characterized by 1H-NMR, 13C-NMR, IR and mass spectroscopy, as well as elemental analysis.

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