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Synthesis of novel 2-substituted benzimidazole derivatives as potential anti microbial agents

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Author(s): Panneer Selvam, T. | P. P. Radhika | S. Janagaraj | A. Siva Kumar

Journal: Research in Biotechnology
ISSN 2229-791X

Volume: 2;
Issue: 3;
Start page: 50;
Date: 2011;
Original page

Keywords: Benzimidazoles | Antibacterial | Antifungal

ABSTRACT
In the present study, a novel series of 2-substituted benzimidazole derivatives weresynthesized and characterized by means of IR, 1H-NMR, 13C- NMR, mass spectral andelemental analysis. The compounds were screened for antibacterial (Staphylococcus aureusATCC9144, Staphylococcus epidermidis ATCC 155, klebsiella pneumoniae ATCC 29665 andEsherichia coli ATCC 25922) and antifungal (Candida albicans ATCC 2091 and Aspergillusniger ATCC 9029) activities. The Minimum Inhibitory Concentrations was determined byagar streak dilution method. 1-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-3-chloro-4-(4-nitrophenyl)azetidin-2-one (3a) was found to exhibit the most potent in vitro antimicrobialactivity with MIC of 15, 17, 19, 9, 11 and 15 μg/mL against E.coli, K.pneumoniae, S.aureus,S.epidermidis, C.albicans and A.niger respectively. All the other compounds exhibitedmoderate activity against the bacterial and fungal organism tested.

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