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SYNTHESIS OF NOVEL NAPHTHO [2,1-b] FURAN DERIVATIVES AND INVESTIGATION OF ANTIMICROBIAL ACTIVITY FOR THE SUPPRESSION OF PIMPLES

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Author(s): Veena K | Shashikaladevi | Ramaiah M | Vaidya V. P

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 9;
Start page: 77;
Date: 2011;
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Keywords: antibacterial | antifungal | Procaine penicillin | Streptomycin | Griseofulvin Naphtho [2 | 1- b] furan.

ABSTRACT
The title compounds 3-nitro-2-acetylnaphtho[2,1-b]furan,3-nitroacetylnaphtho [2,1-b]furanhydrazone,Ethyl-3-aminonaphtho[2,1-b]furan-carboxylate,ethyl (2,5-dimethylpyrrole)naphtho[2,1-b]furan-2-carboxylate, 3-(2,5 dimethylpyrrolenaphtho [2,1-b] furan-2 carboxyhydrazide were synthesized from 2-hydroxy-1-naphthaldehyde which was thought of to be a good starting material, which was prepared from 2-naphthol by Reimer Tiemann reaction. The synthesized compounds were characterized by analytical and spectral studies and were screened for antibacterial activity against gram +ve Staphylococcus aureus, B. subtilis and gram–ve Escherchia coli, Pseudomonas aureus and antifungal activity against Candida albicans, Aspergillus niger by cup plate method.
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