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SYNTHESIS OF SOME N-(BENZOTHIAZOL-2-YL)-2-(4H-[1,2,4]TRIAZOL -3- YLSULFANYL)ACETAMIDES AND THEIR ANTIMICROBIAL ACTIVITY

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Author(s): Ahmet ÖZDEMİR | Zafer Asım KAPLANCIKLI | Gülhan TURAN ZITOUNI | Mehlika Dilek ALTINTOP | Fatih DEMİRCI

Journal: Anadolu University Journal of Science and Technology - C. Life Sciences and Biotechnology
ISSN 2146-0264

Volume: 1;
Issue: 2;
Start page: 145;
Date: 2011;
Original page

Keywords: Benzothiazole | Triazole | Antimicrobial activity

ABSTRACT
The aim of this study is to synthesize novel benzothiazolyl-amide derivatives and investigate their antimicrobial activities. N-(Benzothiazol-2-yl)-2-(4H-[1,2,4]triazol-3-ylsulfanyl) acetamide deriva- tives (3a-j) were prepared by the reaction of N-(benzothiazol-2-yl)-2-chloroacetamides (1a-e) with appropriate 4H-[1,2,4]triazol-2-thione (2a-b). The chemical structures of the compounds were eluci- dated by elemental analyses, IR, ¹H-NMR, ¹³C-NMR and FAB+-MS spectral data. Their antimicrobial activities against Escherichia coli (NRRL B-3008), Staphylococcus aureus (ATCC 6538), Pseudomo- nas aeruginosa (ATCC 27853), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (ATCC 13311), Methicillin-resistant Staphylococcus aureus (MRSA) (clinic isolate), Candida albicans (NRRL Y-12983) and Candida parapsilosis (NRRL Y-12696) were investigated. The results showed that all of the tested compounds were inactive against the test organisms
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