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Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound

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Author(s): Milica Milenković | Beata Warżajtis | Urszula Rychlewska | Dušanka Radanović | Katarina Anđelković | Tatjana Božić | Miroslava Vujčić | Dušan Sladić

Journal: Molecules
ISSN 1420-3049

Volume: 17;
Issue: 3;
Start page: 2567;
Date: 2012;
Original page

Keywords: hydrazine bridged diphosphonium compound | DNA cleavage | brine shrimp test | X-ray

ABSTRACT
The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.
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