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SYNTHESIS, X-RAY AND ANTIMICROBIAL ACTIVITY OF ISATIN-3-PHENYLHYDRAZONE

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Author(s): SANDRA S. KONSTANTINOVIĆ | AGNEŠ KAPOR | BLAGA C. RADOVANOVIĆ | ANDREA DEAK

Journal: Chemical Industry and Chemical Engineering Quarterly
ISSN 1451-9372

Volume: 14;
Issue: 1;
Start page: 27;
Date: 2008;
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Keywords: isatin-3-phenylhydrazone | crystal structure | antimicrobial activity | photolytic stability.

ABSTRACT
Isatin-3-phenylhydrazone was synthesized and X-ray crystal structure of this compound has been solved. Its structure was also established using FTIR, UV/Vis and 1H-NMR spectroscopic method. The compound was tested for antimicrobial activity against Staphylococcus aureus, Bacillus subtilus, Enterococcus D, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa and Candida albicans. Stability of isatin-3-phenylhydrazone toward UV-A irradiation has been studied in this work. Isatin derivative undergoes bleaching following first-order kinetics.
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