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Synthetic, structural and biological studies of organosilicon(IV) complexes of Schiff bases derived from pyrrole-2-carboxaldehyde

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Author(s): KIRAN SING | DHARAM PAL

Journal: Journal of the Serbian Chemical Society
ISSN 0352-5139

Volume: 75;
Issue: 7;
Start page: 917;
Date: 2010;
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Keywords: antifungal | antibacterial | silicon complexes | s-triazole | Schiff bases

ABSTRACT
Selected new organosilicon(IV) complexes having the general formula R2SiCl[L] and R2Si[L] 2 were synthesized by the reactions of Me2SiCl2 with Schiff bases (5-mercapto-4-[(1H-pyrrol-2ylmethylene)amino]-s-triazole, 5-mercapto-3-methyl-4-[(1H-pyrrol-2ylmethylene)amino]-s-triazole and 3-ethyl-5-mercapto-4-[(1H-pyrrol-2ylmethylene)amino]-s-triazole) in 1:1 and 1:2 molar ratios. All of the compounds were characterized by elemental analysis, molar conductance, and IR, UV, 1H-, 13C- and 29Si-NMR spectral studies. All the spectral data suggest an involvement with an azomethine nitrogen in coordination to the central silicon atom. With the help of above-mentioned spectral studies, penta and hexacoordinated environments around the central silicon atoms in the 1:1 and 1:2 complexes, respectively, are proposed. Finally, the free ligands and their metal complexes were tested in vitro against some pathogenic bacteria and fungi to assess their antimicrobial properties.
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Tango Jona
Tangokurs Rapperswil-Jona