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TARGETTED DRUG DELIVERY SYSTEM OF TRIMETAZIDINE HYDROCHLORIDE MICROSPHERES FOR ANGINA PECTORIS

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Author(s): Anil Kumar.S.N.

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 6;
Start page: 14;
Date: 2010;
Original page

Keywords: Pulsatile | Chronopharmaceutics | Angina pectoris | Trimetazidine Hydrochloride | Chitosan.

ABSTRACT
Colon targeting is naturally of value for the tropical treatment of colonic diseases of colonic diseases and for the chronopharmaceutical delivery of drugs. The aim of the present study is to develop colon targeted drug delivery systems for Trimetazidine hydrochloride using Chitosan as a carrier. In this study, investigation of an oral colon specific, pulsatile device to achieve time or site specific release of Trimetazidine, based on chronopharmaceutical considerations. Bodies of gelatin capsules were made insoluble by formaldehyde treatment. Drug loaded microspheres were prepared by emulsification technique. The microspheres equivalent to 40 mg of the drug filled the treated capsules shells, plugged with hydrogel polymers at different concentrations and completely coated with 5 % cellulose Aceteate Phthalate, so that the variability in gastric emptying time can be overcome and a colon-specific release can be achieved. The trimetazidine microsphere were prepared, evaluated for the FTIR study, surface morphology, particle size, drug content, and from the obtained results one better formulation was selected for further fabrication of pulsatile capsule. Different concentration of the hydrogel polymers were used as plugs, to maintain a suitable lag period and it was found that the drug release was controlled by the proportion of polymers used. FTIR study confirmed that there was no interaction between drug and polymer, the shape of microsphere was found to be spherical by SEM studies. In vitro release studies of pulsatile device revealed that, increasing the hydrophilic polymer content resulted in delayed release of trimetazidine from microspheres.
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