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Temperature and Magnetic Resonance Characteristics of Zinc, Manganese, Gadolinium, Gold, Iron Magnetic Nanoparticles and Cytokine Synergy in Hyperthermia

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Author(s): Saleh S. Hayek | Rakesh Sharma | Soonjo Kwon | Avdhesh Sharma | Ching J.Chen

Journal: Journal of Biomedical Science and Engineering
ISSN 1937-6871

Volume: 01;
Issue: 03;
Start page: 182;
Date: 2008;
Original page

Keywords: hyperthermia | nanoparticles | tempera-ture imaging

ABSTRACT
The temperature and magnetic moment depend-ence for assessing localized heating utilizing a new class of Manganese-Zinc-Gadolinium mag-netic nanoparticles was studied. These particles showed heating effect when subjected to alter-nating filed. Alternatively, a new approach was used to get disperse heating without spot heating by using the synthesis of particles at controlled Curie temperature of less than 44oC. The study reports a simple synthesis of Mn0.5Zn0.5GdxFe(2-x)O4 nanoparticles using chemical co- precipita-tion technique. The particles exhibited Curie temperature of 42篊 and high magnitude of mag-netic moments. The particles showed sigmoid behavior of dependence between temperature and magnetic moments. The Nuclear Magnetic Resonance spectroscopy showed T1 depend-ence on temperature in the range of 10-45篊. The particles may have high promise for self con-trolled magnetic hyperthermia application and its monitoring.
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Tango Jona
Tangokurs Rapperswil-Jona