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Teratomas in central nervous system: A clinico-morphological study with review of literature

Author(s): Agrawal Meetu | Uppin Megha | Patibandla Mohana | Bhattacharjee Suchanda | Panigrahi Manas | Saradhi Vijay | Rani Jyotsna | Purohit A | Challa Sundaram

Journal: Neurology India
ISSN 0028-3886

Volume: 58;
Issue: 6;
Start page: 841;
Date: 2010;
Original page

Keywords: CNS | teratoma | terato-carcinoma

Background: Cranio-spinal axis teratomas are rare. This subset is interesting because symptoms can be varied, depending on the location. Histopathology is diagnostic; most of the lesions are benign. Rarely, malignancy develops in any of the somatic components. Aims: To study the demographic, clinico-morphological and follow-up data of central nervous system (CNS) teratomas. Materials and Methods: Cases diagnosed as mature or immature teratomas in the CNS over a 20-year period were included in the study. Clinico-radiological, demographic and follow-up data of these cases were analyzed. Results: A total of 14 tumors were diagnosed as teratomas. Of these, 11 were mature cystic teratomas; and 1 case each, of teratoma with malignant transformation, terato-carcinoma and mixed germ cell tumor (immature teratoma with germinoma). Six of the 14 cases were intracranial and 8 were spinal. Presenting features varied according to the location. Radiologically, contrast enhancement with predominantly solid component was suggestive of malignancy or an aggressive tumor. Morphologically, a variety of tissue derivatives were seen in the cases. Excision was curative or provided symptomatic relief in most cases; terato-carcinoma and mixed germ cell tumor patients needed adjuvant radiotherapy. Conclusion: CNS teratomas are rare. Morphology and location decide outcome.

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