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TESTING EFFICACY OF HERBAL DRUG “FORTEGE” IN TREATMENT OF METAL INDUCED INFERTILITY IN MALE MICE

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Author(s): Mahesh Mishra* and Asha Mathur

Journal: International Journal of Pharmaceutical Sciences and Research
ISSN 0975-8232

Volume: 4;
Issue: 4;
Start page: 1521;
Date: 2013;
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Keywords: Fortege | Lanthanum | Athenospermia | Seminal vesicle

ABSTRACT
ABSTRACT: Fertility was tested in 0.5 mM/kg b. wt. (i.p) Lanthanum chloride exposed mice. Beneficial effects of “Fortege” an ayurvedic medicine (Alarsin co. Bombay) were also tested. Lanthanum chloride affected sperm count and motility. Lanthanum chloride could have affected Sertoli cells adversely and that have reduced sperm’s ability of uptake of fructose and as a result of it sperms became unable to reach ovum and thus antifertility was shown. Maximum effects of Lanthanum chloride were on the weight of seminal vesicles and their fructose content. When such mice were exposed to “fortege” for 21 days and the efficacy obtained, was 87.5%. Only way to overcome Lanthanum toxicity is to remove Lanthanum from the tissues. For the removal of Lanthanum from the body tissues, the chelating activity of some alkaloids of these plants can be considered as the one of the main reason and it is supplemented by improvement in testosterone and LH level.
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