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Tetranectin Binds to the Kringle 1-4 Form of Angiostatin and Modifies Its Functional Activity

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Author(s): Mogues Tirsit | Etzerodt Michael | Hall Crystal | Engelich Georg | Graversen Jonas H. | Hartshorn Kevan L.

Journal: Journal of Biomedicine and Biotechnology
ISSN 1110-7243

Volume: 2004;
Issue: 2;
Start page: 73;
Date: 2004;
Original page

ABSTRACT
Tetranectin is a plasminogen kringle 4 domain-binding protein present in plasma and various tissue locations. Decreased plasma tetranectin or increased tetranectin in stroma of cancers correlates with cancer progression and adverse prognosis. A possible mechanism through which tetranectin could influence cancer progression is by altering activities of plasminogen or the plasminogen fragment, angiostatin. Tetranectin was found to bind to the kringle 1-4 form of angiostatin (AST K1-4 ). In addition, tetranectin inhibited binding of plasminogen or AST K1-4 to extracellular matrix (ECM) deposited by endothelial cells. Finally, tetranectin partially counteracted the ability of AST K1-4 to inhibit proliferation of endothelial cells. This latter effect of tetranectin was specific for AST K1-4 since it did not counteract the antiproliferative activities of the kringle 1-3 form of angiostatin (AST K1-3 ) or endostatin. These findings suggest that tetranectin may modulate angiogenesis through interactions with AST.
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