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Th1 and Th2 Cytokine Profiles in Malignant Pleural Effusion

Author(s): Mohammad Ali Ghayumi | Zahra Mojtahedi | Mohammad Javad Fattahi

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 8;
Issue: 4;
Start page: 195;
Date: 2011;
Original page

Keywords: IFN-γ | IL-4 | Lung Cancer | Pleural Effusion

Background: The alteration of Th1 and Th2 cytokine levels is the subject of controversyin pleural effusions caused by malignancy, a situation that favors a Th2 immuneresponse. Objective: To examine the different levels of IL-4 and IL-10 (Th2 cytokines),and IL-2 and interferon-γ (IFN-γ) (Th1 cytokines) in malignant and non-malignant pleuraleffusions. Method: The cytokine levels in pleural fluid of 62 patients with malignantpleural effusion (44 with lung cancer and 18 with extrathoracic tumors), 8 with tuberculousand 8 with congestive heart failure pleural effusion were analysed using enzymelinkedimmunosorbent assays. Results: IL-2 was below the detectable concentration ofthe assay. A significant decrease in IFN-γ level was observed in malignant but not incongestive heart failure cases compared to tuberculous cases. IL-10 levels were higherin malignant and tuberculous pleural effusions than in congestive heart failure pleuraleffusions, however, this difference did not reach the significant level. IL-4 levels werealso increased non-significantly in lung cancer pleural effusions compared to the othergroups. Conclusion: Our results show a wide variation in IL-4, IL-10, and IFN-γ levelsin malignant pleural effusions, a pattern which was not convincing enough to differentiatethe cause of effusion.
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