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THEORIES AND FACTORS AFFECTING MUCOADHESIVE DRUG DELIVERY SYSTEMS: A REVIEW

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Author(s): Alexander Amit | Sharma Sharad | Ajazuddin | Khan Mohammed Junaid | Swarna

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 4;
Start page: 1155;
Date: 2011;
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Keywords: Drug delivery | Polymer | Adsorption & Bioadhesion.

ABSTRACT
Bioadhesion is an interfacial phenomenon in which two materials, at least one of which is biological, are held together by means of interfacial forces. When the associated biological system is mucous, it is called mucoadhesion. This property of certain polymeric systems have got place in the drug delivery research in order to prolong contact time in the various mucosal route of drug administration, as the ability to maintain a delivery system at a particular location for an extended period of time has a great appeal for both local action as well as systemic drug bioavailability. A complete and comprehensive theory that can predict adhesion based on the chemical and/or physical nature of a polymer is not yet available. Several theories have been proposed to explain the fundamental mechanisms of adhesion such as glues, adhesives, and paints, have been adopted to study the mucoadhesion. Mucoadhesion is a complex process and numerous theories have been presented to explain the mechanisms involved. These theories include mechanical-interlocking, electrostatic, diffusion–interpenetration, adsorption and fracture processes. They are Electronic theory, Adsorption theory, Wetting theory, Diffusion theory, Fracture theory. The objective of the study is to explain the different mechanisms involved in mucoadhesion and various factors affecting mucoadhesion.

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