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Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections

Author(s): Håvard Jenssen

Journal: Viruses
ISSN 1999-4915

Volume: 1;
Issue: 3;
Start page: 939;
Date: 2009;
Original page

Keywords: cationic host defence peptides | antiviral therapy | herpes | antimicrobial peptides | innate defense regulators | immune stimulation

One of the most common viral infections in humans is caused by herpes simplex virus (HSV). It can easily be treated with nucleoside analogues (e.g., acyclovir), but resistant strains are on the rise. Naturally occurring antimicrobial peptides have been demonstrated to possess antiviral activity against HSV. New evidence has also indicated that these host defence peptides are able to selectively stimulate the innate immune system to fight of infections. This review will focus on the anti-HSV activity of such peptides (both natural and synthetic), describe their mode of action and their clinical potential.
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