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Therapeutic Potentials of Silver Nanoparticle Complex of α-Lipoic Acid

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Author(s): Lakshmy Ramachandran | Cherupally Krishnan Krishnan Nair

Journal: Nanomaterials and Nanotechnology
ISSN 1847-9804

Volume: 1;
Issue: 2;
Date: 2011;
Original page

Keywords: silver nanoparticle | lipoic acid | anti‐ inflammatory | anti tumor | radiotherapy

ABSTRACT
Silver (SN) nanoparticles were re‐dispersed in aqueous solution of Pluronic F127 and complexed with the antioxidant, alpha‐ Lipoic acid (LA). The nanoparticle ‐ LA complex (SN‐LA) was characterized using SEM. SN‐ LA exhibited DPPH radical scavenging activity in vitro and anti‐ inflammatory activity against acute and chronic paw models of edema in mice. SN‐LA protected mice from whole body gamma radiation induced body weight losses and mortality revealing its radioprotecting capacity. Meanwhile, SN‐LA administration to tumour‐ bearing mice prior to whole body gamma radiation exposure, aided in better tumour growth delay. The results suggest the feasibility in using SN‐LA as a therapeutic adjuvant during cancer radiotherapy.
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