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THERMAL BEHAVIOR OF PARACETAMOL AND TABLETS OF REFERENCE, GENÉRIC AND SIMILAR

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Author(s): MORAIS, Francisca Edivânia | CABRAL, Sheila Pricila Marques | ARAUJO, Eliane Gonçalves | MARTINEZ-HUITLE, Carlos Alberto | FERNANDES, Nedja Suely

Journal: Periódico Tchê Química
ISSN 1806-0374

Volume: 9;
Issue: 17;
Start page: 28;
Date: 2012;
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Keywords: Paracetamol | thermal analysis | thermal decomposition | drugs

ABSTRACT
The present study utilized the thermoanalytical techniques (TG, DTG, DTA and DSC) to evaluate thethermal behavior of tablets containing paracetamol and marketed as reference, generic and similar. Thesamples were also characterized by IR, X-ray diffraction and SEM. The TG/DTG curves presented similarbehaviour indicanting a low influence of the excipients present in pharmaceutical formulations. The DTA andDSC curves showed an endothermic peak between about 165.0 and 195.0 oC characteristic of melting ofparacetamol in all samples. The X-ray diffraction patterns showed similarities and characterized the compoundsas crystallines. The micrographs indicated heterogeneity in particle size.
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