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Three Novel Xanthones from Garcinia paucinervis and Their Anti-TMV Activity

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Author(s): Yu-Ping Wu | Wei Zhao | Zhen-Yuan Xia | Guang-Hui Kong | Xiu-Ping Lu | Qiu-Fen Hu | Xue-Mei Gao

Journal: Molecules
ISSN 1420-3049

Volume: 18;
Issue: 8;
Start page: 9663;
Date: 2013;
Original page

Keywords: Garcinia paucinervis | xanthones | anti-tobacco mosaic virus

ABSTRACT
Phytochemical investigations of the leaves of Garcinia paucinervis resulted in the isolation of three new xanthones 1–3 and five known analogues 4–8. Structural elucidations of 1–3 were performed by spectral methods such as 1D and 2D (HMQC, HMBC, and ROESY) NMR spectroscopy, in addition to high resolution mass spectrometry. Compounds 1–3 showed anti-TMV activities, with inhibition rates above 20%, especially for 1, which had a lower IC50 value of 21.4 µM.
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