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Thrombophilic risk factors in women with recurrent abortion

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Author(s): Osman Yokuş | Özlem Şahin Balçık | Murat Albayrak | Funda Ceran | Mesude Yılmaz | Simten Dağdaş | Gülsüm Özet

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 1;
Issue: 3;
Start page: 168;
Date: 2010;
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Keywords: thrombophilia | clinical thrombophilia | recurrent abortion | factor V Leiden gene mutation | actived protein-C resistance | methylenetetrahydrofolate reductase gene mutation | prothrombin G20210A gene mutation | protein C deficiency | protein S deficiency | anticardiolipin antibody | lupus anticoagulant

ABSTRACT
Objectives: The aim of this study was to determine the thrombophilic risk factors and their frequency among women with history of recurrent abortion and a detected thrombophilic defect.Materials and methods: In this study, 41 women with history of recurrent abortion, who have one or more detected thrombophilic defects including protein S, protein C, antithrombin deficiency, activated protein C resistance (APC-R), factor V Leiden (FVL), prothrombin G 20210A (PTG), methylenetetrahydrofolate reductase (MTHFR) C677 T gene mutation, antiphospholipid antibodies and elevated levels of factor VIII were retrospectively investigated.Results: The most common detected thrombophilia defect (53.7%) was MTHFR gene mutation. While 22 of 41 patients (53.7%) had more than one concomitant defect, 20 of them had two concomitant defects and the remaining had three defects.Conclusion: MTHFR gene mutation, alone and/or with, concurrent thrombophilic defects was the most frequent factor for hereditary thrombophilia among our patients with a history of recurrent abortion. J Clin Exp Invest 2010; 1(3): 168-172
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