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Thymidylate synthase (TS) tandem repeat promoter polymorphism and susceptibility to colorectal cancer of romanian subjects

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Author(s): Mihai TOMA | Monica STAVARACHI | Dănuţ CIMPONERIU | Pompilia APOSTOL | Traean BURCOŞ | Emil POPA | Nicolae PANDURU | Irina RADU | Lucian GAVRILĂ

Journal: Analele Universitatii din Oradea, Fascicula Biologie
ISSN 1224-5119

Volume: TOM XVII;
Issue: 1;
Start page: 196;
Date: 2010;
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Keywords: colorectal cancer | folate pathway | TS polymorphism | PCR-RFLP

ABSTRACT
The risk of colorectal cancer (CRC) is influence by polymorphisms located in the genes encoding enzymes of the folate pathway. The aim of this study was to evaluate if 2R/3R TS (rs34743033) polymorphism is involved in predisposition for colorectal in Romanian subjects. In the present case-control study, 75 sporadic CRC subjects and 60 healthy controls were genotyped by PCR method. The frequency of 3R/3R genotype was 40% in control group and 42.7% in cancer group. We found that there was no statistically significant association between the risk for CRC and 2R/3R TS polymorphism in Romanian subjects.
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