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Tissue Specific Expression of Testicular Glutathione S-transferases on -methylcholanthrene Treatment

Author(s): K. Vasundhara | B. Hemavathi | K. Thyagaraju

Journal: International Journal of Cancer Research
ISSN 1811-9727

Volume: 2;
Issue: 1;
Start page: 69;
Date: 2006;
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Keywords: Glutathione s-transferases | testis | $-methylcholanthrene

3; 24%) and GST Yn1 (Y; 20%). The substrate specificity studies, purification of SDS PAGE analysis and histopathological studies of long-term treatment with low dosage of -methylcholanthrene, reveals less effect in testis. Where as on short-term treatment with high dosage of -methylcholanthrene, more degenerative changes were observed when compared to long-term treatment. Majority of rat testicular GSTs are Yb sized and are involved in the prevention of initiation in carcinogenesis. To encounter oxidative damage or attack and other stress conditions due to -methylcholanthrene Yc and Yb subunits were elevated.]]>
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