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Topiramate and Sodium Valproate as Adjunctive Therapy to Lithium Carbonate in Treatment of Bipolar Disorder in Adolescents: A Randomized Clinical Trial

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Author(s): Javad Mahmoudi-gharaei | Javad Alaghband-rad | Farhad Faridhoseini | Mohammad Reza Mohammadi | Mahdi Tehranidoost | Zahra Shahrivar | Padideh Ghaeli | Toktam Faghihi

Journal: Iranian Journal of Psychiatry and Clinical Psychology
ISSN 1735-4315

Volume: 14;
Issue: 2;
Start page: 122;
Date: 2008;
Original page

Keywords: bipolar disorder | adolescents | mood stabilizer | sodium valproate | topiramate | lithium | mania

ABSTRACT
Objectives: In this study the effect of topiramate as adjunctive therapy to lithium on mood disorder in adolescents is compared to that of sodium valproate.Method: In a randomized clinical trial, 30 adolescents with bipolar mood disorder in the manic or mixed phase were treated with either topiramate or sodium valproate. All participants had either not responded adequately to a 4 to 6 week period of treatment with lithium carbonate, or had relapsed after a period of remission and needed additional mood-stabilizing drug. Responses were evaluated using Young Mania Rating Scale, Clinical Global Impression Scale and Children Global Assessment Scale.Results: Many of the demographic properties of both groups were similar. In each group the mean of the decrease in symptoms and degree of remission were significant (p

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