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Total anesthesia, rats brain surgery, nitric oxide (NO) and free radicals

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Author(s): Jelenković Ankica V. | Jovanović Marina | Ninković Milica | Maksimović M. | Bošković Bogdan

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 55;
Issue: 5-6;
Start page: 375;
Date: 2005;
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Keywords: brain | lipid peroxidation | nitric oxide | oxidative stress | pentobarbital | surgery

ABSTRACT
It is expected that clinical recovery after surgically induced brain trauma is followed by molecular and biochemical restitution. Seven days after surgery, we investigated whether the plastic cannula implanted in the left brain ventricle of adult Wistar rats (n = 6-7), performed in pentobarbital anesthesia, could influence oxidative stress elements (superoxide anion and lipid peroxidation), as well as the antioxidative system (superoxide dismuthase-SOD). Also, we investigated whether nitric oxide (NO) is involved in these processes. Biochemical analyses was performed in the forebrain cortex, striatum and hippocampus. Clinical recovery was complete seven days after surgery. Thereafter, thirty minutes before decapitation, through the cannula, one group of rats received saline intracerebroventricularly (control group), and the treated group received Nω-nitro-L-arginine methyl ester (L-NAME). The third group was left unoperated and untreated. Before and after the treatments, rectal body temperature was measured. Compared to the untreated group the index of lipid peroxidation was increased in all three brain structures in the group that received saline (p
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