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Toxic effect of ciprofloxacin on some biochemical variables in chicks

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Author(s): Y. Z. Salih

Journal: Iraqi Journal of Veterinary Sciences
ISSN 1607-3894

Volume: 24 (Arabic);
Issue: 2;
Start page: 137;
Date: 2010;
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ABSTRACT
The aim of the present study was to examine the acute and sub acute toxicity of ciprofloxacin on lipids metabolism ofchicks which included determination of cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, and albuminlevels in serum of chicks. The biochemical changes induced by giving ciprofloxacin as a single dose (200 and 400 mg/kg.body weight intraperitoneally) included significant increases of cholesterol, triglyceride and low density lipoprotein levels inserum, whereas albumin level significantly decreased, and there was no significant changes in high density lipoprotein levelsas compared with control group. Repeated treatment with ciprofloxacin (100 mg/kg. body weight intra peritoneal) for 14 dayscaused significant increase in cholesterol level, albumin level significantly decreased as compared with control group, whereasit did not change significantly high density lipoprotein and triglyceride levels, repeated treatment of ciprofloxacin also showedsignificant decrease of the body weights of the chicks as compared with control group. The results suggest that there are toxiceffects of ciprofloxacin on lipids metabolism as seen through changes in cholesterol, triglyceride, albumin and low densitylipoprotein level.

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