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Toxic response of occupational exposure to ethylene oxide, with particular reference to its respiratory effects

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Author(s): M. Neghab | E. Soleimani

Journal: Iran Occupational Health
ISSN 1735-5133

Volume: 8;
Issue: 1;
Start page: 41;
Date: 2011;
Original page

Keywords: Ethylene oxide | occupational exposure | respiratory disorders | intoxication symptoms

ABSTRACT
  Background and Aims Ethylene oxide is used as a sterilizing agent in health care industries. The present study aimed to assess and recognize the nature of pulmonary reactions, if any, associated with occupational exposure to ethylene oxide and to investigate the prevalence of dermal, visual, neurologic, reproductive, hematologic, hepatic and renal disorders .   Methods  Forty exposed and 47 unexposed employees were evaluated . Subjects were interviewed and standard respiratory symptom questionnaire as well as a questionnaire pertaining to symptoms of intoxication with this chemical were administered to them. Furthermore, parameters of pulmonary function were measured during exposure and a few days after exposure ceased Additionally, blood samples were taken for CBC, liver and kidney function tests . Moreover, atmospheric concentrations of ethylene oxide were determined by gas detector tubes .   Results  Respiratory symptoms such as cough and phlegm as well as dermal, visual and neurologic symptoms in exposed workers were significantly more prevalent P≤0.05 . Furthermore, significant decrements in some parameters of pulmonary function during exposure as compared with the values measured after exposure ceased, were noted . Results of biochemical tests were similar in both groups. Mean atmospheric concentration of ethylene oxide was evaluated to be 1.24±1.5 ppm.   Conclusion  The findings of this study indicate that exposure to ethylene oxide even at low concentrations is associated with significant decreases in pulmonary parameters. However, this effect is acute, temporary and reversible. Conversely, exposure to ethylene oxide was not associated with hematotoxic, hepatotoxic and nephrotoxic response, although, dermal, visual and neurologic symptoms were observed.
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