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Toxicity of Asistolochia brcteolata methanolic and chloroformic extracts in rats

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Author(s): Samia H. Abdelrahman, | Khojali S.M.Elbashir, | Tarig H.A.Bilal | Thoria O.Onsa

Journal: Research Opinions in Animal & Veterinary Sciences
ISSN 2221-1896

Volume: 1;
Issue: 1;
Start page: 27;
Date: 2011;
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Keywords: Aristolochia bracteolata | Toxicity | Rats

ABSTRACT
This study was designed to find the toxicological effect of methanolic and chlorformic extract of Aristolochia bracteolata in Swiss albino rats. Methanolic and chlorphormic extracts were given at doses of 250 and 500 mg/kg BW to Swiss albino rats. Oral administration of the extract caused symptoms such as depression, arching of the back and tremors. Serum analysis indicated increase in the activity of Aspartate aminotransferease (AST), Alanine amino transferase (ALT) and Alkaline phosphatase (ALP). The concentration of urea, creatinine, ammonia were also increased and the concentration of total protein decreased. The main lesions found were haemorrage in the kidney and congestion of the liver. We concluded that chloroformic extract at the rate of 500 mg/kg was more toxic than all the treatments.
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