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Toxicological Aspects of Cola acuminata Nut Extracts

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Author(s): Shama I.Y. Adam | Ahmed A.N. Yahya | Wala M.M. Salih | Warda S. Abdelgadir

Journal: British Journal of Pharmacology and Toxicology
ISSN 2044-2459

Volume: 2;
Issue: 4;
Start page: 199;
Date: 2011;
Original page

Keywords: Cola acuminata | hematology | pathological findings | serum chemistry | toxicity

ABSTRACT
The multipurpose medicinal plant, Cola acuminata, was chosen for this investigation. Prominent effects on body weight and weight gain was observed. The toxicity on liver, kidney and heart was correlated with changes in the activity of Aspartate Transaminase (AST) and Alanine Transaminase (ALT), and the concentration of cholesterol, albumin and urea in serum. There was an increase in the neutrophils and decrease in lymphocytes in the blood of all the tested groups and an increase of WBC of two groups only. Cytoplasmic fatty vacuolation or necrosis of the centrilobular hepatocytes catarrhal enteritis with minute erosions of the intestinal epithelium with lymphocytic infiltration in the lamina propria and hemosidrin deposition, shrinkage of the glomerular tufts and dilatation of the proximal convoluted tubules were also seen. In group 3 there were lymphocytic infiltrations, glomerular packing, degeneration or necrosis of the epithelial cells of the renal convoluted tubules. No significant lesions were observed in the heart of the test rats. The vital organs of the control rats remained healthy.
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