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Toxicological, biochemical and histopathological evaluation of Tridham in Wistar albino rats.

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Author(s): Ravindran Jaganathan | Vijaya Ravinayagam | Sachdanandam Panchanadham | Shanthi Palanivelu

Journal: Journal of Biochemical Technology
ISSN 0974-2328

Volume: 4;
Issue: 1;
Start page: 541;
Date: 2012;
Original page

Keywords: Phytochemical research | polyherbal formulation | Toxicological and safety assesment

ABSTRACT
Tridham (TD), a polyherbal formulation is assessed for its acute (72 hr) and subacute toxicity (28 days) and also its significance on histological, hematological and biochemical variations in albino wistar rats. Body weight and general behavior of animal was observed throughout the experimental period and at the end of the study period organ weight, haematological and biochemical parameters of blood and urine, as well as kidney and liver histology were evaluated. Results of the studies performed indicated no toxic clinical symptoms or histopathological lesions in both acute and subacute toxicity, which clearly shows that TD extract has high margin of safety.
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