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Tp53 Expression and Ki-67 Proliferation Index in Surface Epithelial-Stromal Tumors of the Ovary and Their Relationship with the Histopathological Prognostic Parameters

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Author(s): Sevgiye Kaçar Özkara | Deniz Filinte

Journal: Balkan Medical Journal
ISSN 2146-3123

Volume: 28;
Issue: 04;
Start page: 394;
Date: 2011;
Original page

Keywords: Ovarian tumors | p53 | Ki-67

ABSTRACT
Objective: To investigate TP53 and Ki-67 expressions in malignant, borderline and benign epithelial ovarian tumors; correlate results with histopathological parameters; compare TP53 and Ki-67 expressions and discuss ovarian carcinogenesis.Material and Methods: Standard immunohistochemistry was performed in 100 malignant, 27 borderline and 31 benign tumors and 42 non-tumoral ovarian epithelia.Results: TP53 overexpression was higher in malignant (61.0%) than in borderline tumors (40.7%); in malignant cases above 50 years-of-age, with high grade and in undifferentiated and serous subtypes. Carcinomas with solid architecture in serous, high mitosis in non-serous and high pleomorphism in both subtypes; lymph node involvement, and advanced stage also showed higher expressions of TP53 (p
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