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Transcription Regulation by Class III Histone Deacetylases (HDACs)—Sirtuins

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Author(s): Yan Dai | Douglas V. Faller

Journal: Translational Oncogenomics
ISSN 1177-2727

Volume: 3;
Start page: 53;
Date: 2008;
Original page

Keywords: Sirtuins | SIRT1 | transcription | acetylation | deacetylation | HDAC

ABSTRACT
Sirtuins are NAD+-dependent histone deacetylases (Class III HDACs). Recently, Sirtuins have been shown to play important roles, both direct and indirect, in transcriptional regulation. This transcriptional control, through incorporation of Sirtuins into transcription complexes and deacetylation of histones locally at gene promoters, or direct interaction with specific transcription factors, is central to the participation of Sirtuins in multiple diverse processes, including aging, apoptosis, hormone responses, stress tolerance, differentiation, metabolism and development. Here we review the contribution of the Sirtuin family, at multiple molecular levels, to transcriptional regulation.
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