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Transdermal Drug Delivery Systems : A Review

Author(s): Girish Chopda

Journal: Pharmaceutical Reviews
ISSN 1918-5561

Volume: 4;
Issue: 1;
Date: 2006;
Original page

At present, the most common form of delivery of drugs is the oral route. While this has the notable advantage of easy administration, it also has significant drawbacks -- namely poor bioavailabiltity due to hepatic metabolism (first pass) and the tendency to produce rapid blood level spikes (both high and low), leading to a need for high and/or frequent dosing, which can be both cost prohibitive and inconvenient.(1)To overcome these difficulties there is a need for the development of new drugdelivery system; which will improve the therapeutic efficacy and safety of drugsby more precise (ie site specific ) , spatial and temporal placement withinthe body thereby reducing both the size and number of doses. New drug deliverysystem are also essential for the delivery of novel , genetically engineeredpharmaceuticals (ie peptides , proteins ) to their site of action , withoutincurring significant immunogenecity or biological inactivation. Apart fromthese advantages the pharmaceutical companies recognize the possibility of repatteningsuccessfull drugs by appling the concepts and techniques of controlled drugdelivery system coupled with the increased expense in bringing new drug moietyto the market(1).One of the methods most often utilized has been transdermaldelivery - meaning transport of therapeutic substances through the skin forsystemic effect. Closely related is percutaneous delivery, which is transportinto target tissues, with an attempt to AVOID systemic effects (2).
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