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TRANSDERMAL DRUG DELIVERY SYSTEMS: AN OVERVIEW

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Author(s): Azhar Ahmed | Nirmal Karki | Rita Charde | Manoj Charde | Bhushan Gandhare

Journal: International Journal of Biomedical and Advance Research
ISSN 2229-3809

Volume: 2;
Issue: 1;
Start page: 38;
Date: 2011;
Original page

Keywords: Transdermal drug delivery | polymeric formulations | controlled release dosage form

ABSTRACT
With the advent of modern era of pharmaceutical dosage forms, transdermal drug delivery system (TDDS) established itself as an integral part of novel drug delivery systems. Transdermal patches are polymeric formulations which when applied to skin deliver the drug at a predetermined rate across dermis to achieve systemic effects. Transdermal dosage forms, though a costly alternative to conventional formulations, are becoming popular because of their unique advantages. Controlled absorption, more uniform plasma levels, improved bioavailability, reduced side effects, painless and simple application and flexibility of terminating drug administration by simply removing the patch from the skin are some of the potential advantages of transdermal drug delivery. Development of controlled release transdermal dosage form is a complex process involving extensive efforts. This review article describes the methods of preparation of different types of transdermal patches viz., matrix patches, reservoir type, membrane matrix hybrid patches, drug-in-adhesive patches and micro reservoir patches. In addition, the various methods of evaluation of transdermal dosage form have also been reviewed.
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