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Transdifferentiation-inducing HCCR-1 oncogene

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Author(s): Ha Seon-Ah | Kim Hyun | Yoo JinAh | Kim SangHee | Shin Seung | Lee Youn | Hur Soo | Kim Yong | Kim Tae | Chung Yeun | Jeun Shin | Kim Dong | Park Yong | Kim Jin | Shin Soon | Lee Young | Kim Jin

Journal: BMC Cell Biology
ISSN 1471-2121

Volume: 11;
Issue: 1;
Start page: 49;
Date: 2010;
Original page

ABSTRACT
Abstract Background Cell transdifferentiation is characterized by loss of some phenotypes along with acquisition of new phenotypes in differentiated cells. The differentiated state of a given cell is not irreversible. It depends on the up- and downregulation exerted by specific molecules. Results We report here that HCCR-1, previously shown to play an oncogenic role in human cancers, induces epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) in human and mouse, respectively. The stem cell factor receptor CD117/c-Kit was induced in this transdifferentiated (EMT) sarcoma tissues. This MET occurring in HCCR-1 transfected cells is reminiscent of the transdifferentiation process during nephrogenesis. Indeed, expression of HCCR-1 was observed during the embryonic development of the kidney. This suggests that HCCR-1 might be involved in the transdifferentiation process of cancer stem cell. Conclusions Therefore, we propose that HCCR-1 may be a regulatory factor that stimulates morphogenesis of epithelia or mesenchyme during neoplastic transformation.
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