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Transformation of chronic lymphocytic leukemia to mantle cell lymphoma: A case report

Author(s): Özlem Şahin Balcık | Derya Akdeniz | Kadir Serkan Yalçın | Ümit Akyıldız | Esra Atıcı | Sonay Güven | Ali Koşar

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 2;
Issue: 4;
Start page: 443;
Date: 2011;
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Keywords: Chronic lymphocytic leukemia | Mantle cell lymphoma | Richter transformation

Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disease characterized by clonal expansion of B lymphocytes. Richter Transformation (RT) must be considered if CLL patient had fever, weight loss, cytopenia and resistance to standard therapy. Despite CLL usually transforms to diffuse large cell lymphoma, some rare lymphomas may occur as RT such as Hodgkin variants, lymphoblastic lymphoma nad mantle cell lymphoma. Here, we report a case of Mantle cell lymphoma has become secondary to chronic lymphocytic leukemia due to its being a rare entity. J Clin Exp Invest 2011; 2 (4): 443-445
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