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Transient normoprolactinemic galactorrhea induced by fluoxetine

Author(s): Fatih Canan | Ünsal Aydınoğlu | Gjergji Sinani

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 4;
Issue: 1;
Start page: 105;
Date: 2013;
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Keywords: Fluoxetine | galactorrhea | side effect

Hormonal side effects of antidepressants are infrequent.Galactorrhea is rarely reported among antidepressantrelated side effects. Antidepressants can directly stimulatepostsynaptic 5- Hydroxytryptamine (5-HT) receptorsin the hypothalamus or indirectly inhibit the tuberoinfundibulardopaminergic neurons through 5-HT, which mayincrease prolactin levels and later cause galactorrhea.However, galactorrhea may develop despite normal prolactinlevels during antidepressant treatment. We presenta case of normoprolactinemic galactorrhea in a woman,related with fluoxetine treatment. This report highlightsthe presence of unidentified mechanisms of selectiveserotonin reuptake inhibitor induced galactorrhea. J ClinExp Invest 2013; 4 (1): 105-106Key words: Fluoxetine, galactorrhea, side effect
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