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Transition Metal Catalyzed Synthesis of Aryl Sulfides

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Author(s): Chad C. Eichman | James P. Stambuli

Journal: Molecules
ISSN 1420-3049

Volume: 16;
Issue: 1;
Start page: 590;
Date: 2011;
Original page

Keywords: C-S bond formation | biaryl sulfides | arylation of thiols

ABSTRACT
The presence of aryl sulfides in biologically active compounds has resulted in the development of new methods to form carbon-sulfur bonds. The synthesis of aryl sulfides via metal catalysis has significantly increased in recent years. Historically, thiolates and sulfides have been thought to plague catalyst activity in the presence of transition metals. Indeed, strong coordination of thiolates and thioethers to transition metals can often hinder catalytic activity; however, various catalysts are able to withstand catalyst deactivation and form aryl carbon-sulfur bonds in high-yielding transformations. This review discusses the metal-catalyzed arylation of thiols and the use of disulfides as metal-thiolate precursors for the formation of C-S bonds.

Tango Jona
Tangokurs Rapperswil-Jona

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