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Trend of Memory Recovery after Benzodiazepine Overdose

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Author(s): Nastaran Eizadi-Mood, , , , , , | Ali Mohammad Sabzghabaei | Kamran Montazeri | Farzad Gheshlaghi | Ahmad Yaraghi | Behzad Nazemorraya | Shadi Kazemi

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 6;
Issue: 1;
Start page: 11;
Date: 2007;
Original page

Keywords: Benzodiazepine | Overdose | Amnesia

ABSTRACT
Because of difference in the toxicokinetic and pharmacokinetic characteristics of drugs and with respect to the high rate of benzodiazepine abuse in suicidal attempts, the trend of possible anterograde amnesia after recovery from benzodiazepine overdose were evaluated in Iranian patients. This was a prospective descriptive/analytic clinical trial, which was conducted, in Noor general teaching hospital. Patients 18-50 years old, who had committed suicidal attempts only with long acting benzodiazepines, were tested for memory at 3 times: immediately after waking up (time 0, t0), 12 (time 12, t12) and 24 hours (time 24, t24) after waking up. Memory was assessed using the Wechsler Memory Scale. The mean of memory score was 44.6±7.1 immediately after waking up (t0). This score was 76.9±3.5 and 93.3±8.18 at t12 and t24 respectively. The difference between the means of memory scores of t0 and t12 was statistically significant and this was the same between t12 and t24. There was a statistically significant relationship between memory score and drug dosage. It is concluded the memory status following waking up from benzodiazepine overdose changes during the course of recovery and is ascending in an approximately linear way.
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