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Tribulus terrestris protects rat myocardium against isoproterenol-induced ischemic injury: role of HSP 70 and cardiac endogenous antioxidants

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Author(s): Ipseeta Ray Mohanty | Ujjwala Maheswari | Daniel Joseph | Yeshwant Deshmukh

Journal: Alternative Medicine Studies
ISSN 2038-9477

Volume: 1;
Issue: 1;
Start page: e9;
Date: 2011;
Original page

Keywords: Oxidative stress | Myocardial infarction | Medicinal herbs | Tribulus terrestris | Antioxidants.

ABSTRACT
The present study was undertaken to evaluate the cardioprotective activity of Tribulus terrestris (Tt), a medicinal herb following isoproterenol (ISP)-induced myocardial injury. The contribution of heat shock protein (HSP) 70, key anti-stress protein, endogenous antioxidants and oxidant -antioxidant balance in attenuating myocardial injury was further studied. Hydroalcoholic extract of Tt {1, 2.5, 5 & 10 mg/kg} were orally fed once a daily to Wistar rats for 21 days. On the 20th and 21st day, both control (ISP control) and Tt fed rats were challenged with ISP (85 mg/ kg, s. c. two doses at 24h intervals) induced myocardial necrosis. Histopathological evaluation, cardiac marker enzyme: Creatinine phospho - kinase(CPK) and antioxidative parameters: Glutathione (GSH), Thiobarbituric acid reactive substances (TBARS), Catalase (CAT), Glutathione peroxidase (GSHPx) and Superoxide dismutase (SOD) levels were estimated. Tt (2.5 mg/kg) intake per se upregulated HSP 70; increased basal SOD, CAT activity (P
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