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Tumor Suppressor Role of Notch1 and Raf-1 Signaling in Medullary Thyroid Cancer Cells

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Author(s): Muthusamy Kunnimalaiyaan | Megan R. Haymart | Herbert Chen

Journal: Translational Oncogenomics
ISSN 1177-2727

Volume: 2;
Start page: 43;
Date: 2007;
Original page

Keywords: medullary thyroid cancer | Notch1 | Raf-1 | achaete scute complex-like 1 | Notch1 activating compound | ZM336372

ABSTRACT
There is a growing body of literature suggesting that signaling based therapy might be a potential approach for medullary thyroid cancer (MTC). In this review we focus on the tumor suppressor role of Notch1 and Raf-1 signaling in MTC. Interestingly these two pathways are minimally active or absent in these tumors and activation of Notch1 and Raf-1 significantly reduces tumor growth in vitro. Therefore, identification of compounds that induce these pathways could be a potential strategy to treat patients with MTC.
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