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Type-2 Diabetes Mellitus and Malaria Parasitaemia: Effect on Liver Function Tests

Author(s): Ebele Joy Ikekpeazu | E.E. Neboh; I.C. Maduka; I.J. Nwagbara and M.W. Nwobodo

Journal: Asian Journal of Medical Sciences
ISSN 2040-8765

Volume: 2;
Issue: 5;
Start page: 214;
Date: 2010;
Original page

Keywords: Assessment | diabetic patients | enzymes | liver dysfunction | parasitaemia

Diabetes M ellitus and Malaria have continually been shown to be the major killers common in major developing countries in spite of phenomenal progress in medical sciences. The present study is therefore aimed at assessment of liver function in diabetic patients with malaria infection, hence finding the possible contribution of malaria infection of some organs to the pathophysiology of diabetes mellitus. The liver function profile were estimated in a total of 140 subjects, of which 50 were diabetic patients w ith malaria parasitaemia, 50 diabetics without malaria infection drawn from patients attending the diabetic clinic at the University of Nigeria Teaching Hospital, UNTH, Ituku-Ozalla, Enugu. Fifty (50) non-diabetics without m alaria and 50 non-diabetics with malaria were used as controls. All the subjects were aged between 40-70 years old and were involved in the study. The diagnosis for malaria and diabetes mellitus were made according to WHO guidelines. There w as no significant difference in the mean blood glucose in the diabetics with and those without malaria. The diabetics with malaria and those without malaria showed normal liver function although alkaline phosphatase and bilirubin were slightly raised but non-significant. Both diabetics and non-diabetics with malaria showed slight elevation in alkaline phosphatase, suggesting that diabetics with severe malaria parasitaem ia may be at higher risk of liver dysfunction.
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