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TYROSINE KINASES: NOVEL TARGETS FOR CANCER THERAPY

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Author(s): Neeraj K. Sharma

Journal: Journal of Advanced Scientific Research
ISSN 0976-9595

Volume: 2;
Issue: 1;
Start page: 01;
Date: 2011;
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Keywords: Receptor Tyrosine Kinase | Cancer | Signal Transduction | Phosphorylation | Oncogenes

ABSTRACT
Tyrosine kinases are the enzymes those play a major role in tumor invasion and metastasis. Preclinical and clinical data strongly support the involvement of specific tyrosine kinases in the formation and progression of solid and liquid tumors. Various inhibitors were designed and synthesized for the regulation of tyrosine kinase activity. The present review focuses on to explore distinct characteristics of tyrosine kinases and their involvement in the progression of cancer.
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